Vehicle Mode is the primary mode of travel in the Blaster Master series. In this mode, Sophia (or a variation thereof) is controlled directly with full access to all of the tank's obtained abilities. The main character can exit the tank at any time and enter smaller areas known as Gates, triggering Character Mode.

Only in Blaster Master: Blasting Again are a few boss battles fought in Vehicle Mode, and Blaster Master Boy is devoid of a Vehicle Mode, as Sophia does not appear at all.